AN UNBIASED VIEW OF FENTANYL FOR SURGERY

Istradefylline 40 mg/day enhanced peak levels and AUC of CYP3A4 substrates in clinical trials. This effect wasn't observed with istradefylline twenty mg/day. Consider dose reduction of sensitive CYP3A4 substrates.Concomitant use of fentanyl injection with CYP3A4 inducers or discontinuation of a CYP3A4 inhibitor could reduce fentanyl plasma concentr

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